| CAS No.: | 1094-61-7 |
|---|---|
| Formula: | C11h15n2o8p |
| EINECS: | 214-136-5 |
| Type: | Pharmaceutical Intermediates |
| Appearance: | Powder |
| Quality: | Refined |
| Samples: |
|---|
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The details of NMN / BETA -Nicotinamide Mononucleotide CAS 1094-61-7
Product Name: β-Nicotinamide Mononucleotide
Synonyms: BETA-NMN;BETA-NICOTINAMIDE MONONUCLEOTIDE;BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE;3-(aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium;B-NICOTINAMIDE MONONUCLEOTIDE;NMN;NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE 5'-PHOSPHATE;NICOTINAMIDE RIBOTIDE
CAS: 1094-61-7
MF: C11H15N2O8P
MW: 334.22
EINECS: 214-136-5
Melting point 166 °C(dec.)
storage temp. -20°C
form Solid
color White to Yellow
Merck 13,6697
BRN 3570187
Stability: Very Hygroscopic
Specification of NMN / BETA -Nicotinamide Mononucleotide CAS 1094-61-7
|
NMN/BETA -Nicotinamide Mononucleotide |
|
|
CAS NO. |
1094-61-7 |
|
Appearance |
White or almost white powder |
|
Assay |
99% min |
|
Loss on drying |
Not more than 0.5% |
|
Heavy Metal |
Not more than 10ppm |
|
Chlorides |
Not more than 200 ppm |
|
Sulfates |
Not more than 300 ppm |
|
Iron |
Not more than 20 ppm |
|
As |
Not more than 1 ppm |
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Bulk density |
Not less than 0.15g/ml |
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Shelf Life |
Two years when properly stored. |
Application of NMN / BETA -Nicotinamide Mononucleotide CAS 1094-61-7
β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. NMN is a nucleotide derived from ribose and nicotinamide. Niacinamide (nicotinamide,) is a derivative of vitamin B3, also known as niacin.) As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra.
β-Nicotinamide mononucleotide is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.At 50-100 μM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function.Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels.
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